Dosage and methods of intake:

Generic Temodal is available over the various countries under the dosage of 5 mg, 100 mg, 140 mg, 180 mg and 250 mg oral capsules. The parenteral form also came into use in the later half for people who were unable to swallow oral cancer pills.

For the treatment of adult clients with anaplastic astrocytome the prescribed dose is hundred and fifty milligrams over 90 minutes once a day for 5 consecutive days and for the treatment of glioma the dose is from seventy five milligrams over 90 minutes for 42 days along with radiation.

Temodal Pricing

We pride ourselves on providing our customers with the lowest price cost of Temodal. The cost to you for our Temodal is the lowest price and is most affordable.

Mechanism of action:

Temozolomide commonly referred to TMZ a derivative of the alkylating agent decarbazine undergoes rapid chemical conversion in the systemic circulation at a physiological ph to the active compound monoethyl triazeno imidazole carboxamide. The drug exhibits an anti neoplatic activity where in disrupts the DNA molecule of the tumor cell. Under recent studies it has been shown that temodal along with chemotherapy and radiation therapy improves the free survival and overall survival of the clients.

Pharmacokinetics:

under the four major headings where the reaction of the body to the drug is studied we are able to find out that the drug is absorbed by the intestinal villi present all along the intestine and is taken into the systemic circulation as the drug has 15 percent protein binding capacity it has a half life of 1 to 8 hours. The drug is evenly distributed and crosses the blood brain barrier interfering with the DNA structure of the tumor cells in the brain. The drug is metabolized in the blood stream and excreted in bile and urine. Based on the pharmacokinetics the action of the body in the response to the drug helps us realize the complete nature of the drug and subject to more analysis.

Uses of Generic temodal:

The drug is mainly used in the treatment of brain tumors. Patients with recurrent high grade gliomas like glioblastome multiforme, anaplastic astrocytoma and clients with metastic malignant melanoma. Clients with newly diagnosed glioblastoma multiforme with the combination of radiation therapy and then as an adjuvant treatment.

Cases of contraindication: generic temodal. The 4 major cases that are contraindicated are cases of hypersensitivity conditions; pregnancy states; lactating and breast feeding mothers; myelo suppression.

Other interactions:

You need to consult your doctor regarding the use of other medications and their influence on the action of temodal. Some of the drug that commonly interact with generic temodal are carbamazepine, divalproex sodium, phenytoin, valproic acid, steroids and all sulfa drugs such as bactrim, septra, cotrim and many more.

However these do not include the only ones that interact with temodal it therefore becomes necessary to consult your doctor regarding drug interactions as they could understand the concept more clearly having known the chemical structure of each drug.

Adverse effects of the drug:

The adverse effects of the drug are similar to those of other anti neoplastic drugs and be classified based on the severity of occurrence. Some of the most common and general side effects are allergic reactions including hives, difficulty in respiration and swelling of the face, lips, tongue, throat and extremities. Apart from these side effects the other major side effects include:

• Convulsions

• Tingling of one side of the body

• Signs of an infection

• Bleeding nose and gums

• Dry cough, feeling short of breath, weight loss and night sweats

• Burning micturation

• Soreness of the oral cavity.

• Less serious side effects

• Alopecia

• Feeing fatigued

• Diarrhea and constipation

• Mild skin rashes

• Insomnia and other sleep problems

• Unusual taste sensation

• Dizziness and blurring of vision.

Special considerations to be followed:

• The capsules must be swallowed with a glass of water and not opened or chewed.

• They should be taken on an empty stomach.

• Avoid contact of the damaged capsule with the skin eyes or nose.

• Do not take another pill when you have vomited the previous one.

• Avoid doing strenuous activity once you have taken the drug as it can cause nausea and dizziness.

• Avoid the drug pregnancy as it can cause defects to the unborn child.

• Avoid using the drug over a long period of time as it affects the sperm count and can lead to infertility.

• Consult your doctor in case you have a kidney disease or liver disease.

• Caution while using the drug for elderly clients as bone marrow suppression is a major complication and can result in brittling of bones.